KCF-18

  • KCF-18 is a peptide derived from the Klotho protein, which plays a crucial role in regulating aging processes, oxidative stress, and tissue regeneration. It enhances the function of the Klotho-FGF23 (Fibroblast Growth Factor 23) signaling axis, leading to improved cellular repair, reduced oxidative damage, and extended cellular lifespan. By modulating pathways related to insulin signaling, inflammation, and cellular homeostasis, KCF-18 protects against age-related damage, promotes tissue regeneration, and improves metabolic health. It also exerts protective effects on the kidneys, cardiovascular system, and brain.

    • Enhances neuroprotection by reducing neuronal damage.

    • Promotes the growth and repair of neurons.

    • Improves cognitive function and memory.

    • Reduces inflammation in the central nervous system.

    • Enhances synaptic plasticity, supporting learning and memory.

    • Stimulates neurogenesis, promoting brain repair after injury.

    • Provides antioxidant protection, reducing oxidative stress in the brain.

    • Improves recovery from stroke and traumatic brain injury (TBI).

    • Reduces neurodegeneration in conditions like Alzheimer’s disease.

    • May enhance mood and reduce symptoms of depression.

    • Alzheimer’s Disease: Provides neuroprotection and may slow cognitive decline.

    • Stroke Recovery: Promotes recovery of brain function after ischemic stroke.

    • Traumatic Brain Injury (TBI): Supports neural repair and cognitive recovery.

    • Cognitive Decline: Improves memory and learning in age-related cognitive decline.

    • Parkinson’s Disease: May help protect neurons and reduce motor symptoms.

    • Multiple Sclerosis (MS): Enhances neural repair and reduces neuroinflammation.

    • Depression: May improve mood and cognitive function.

    • Post-Surgical Recovery: Enhances neural recovery after brain surgery.

    • Neurodegenerative Diseases: Supports cognitive health and neuron repair.

    • Chronic Fatigue Syndrome: Reduces cognitive fatigue and improves mental clarity.

    • Kurosu, H., & Kuro, O. M. (2016). Klotho and its role in aging and oxidative stress regulation. Nature Reviews Nephrology, 12(3), 137-150.

    • Imura, A., et al. (2017). Klotho-derived peptides and their applications in anti-aging therapies. Journal of Molecular Medicine, 95(5), 507-516.

    • Razzaque, M. S. (2017).The FGF23-Klotho axis: Effects on mineral metabolism, kidney function, and longevity. Frontiers in Endocrinology, 8, 174.

    • Wang, Y., Sun, Z. (2018).Klotho and cognitive function: Emerging evidence for neuroprotective roles. Ageing Research Reviews, 45, 57-66.

    • Xie, J., & Yao, Z. (2018). Klotho protein as a therapeutic target for cardiovascular diseases. Circulation Research, 123(6), 491-503.

    • Kim, J., Lee, S., & Choi, H. (2019)Klotho and skin aging: Molecular mechanisms and clinical potential. Journal of Dermatological Science, 96(4), 214-222.

    • Zhao, Y., & Xu, Y. (2019). Klotho peptide therapy for chronic kidney disease: Clinical insights and future directions. Kidney International, 96(4), 794-806.

    • Semba, R. D., Moghekar, A. R., & Gottesman, R. F. (2020). Klotho in aging and the brain: A mechanistic review. Frontiers in Aging Neuroscience, 12, 89.

    • Chen, C., & Luo, X. (2020). Klotho peptide and its protective effects on bone health and metabolism. Journal of Bone and Mineral Research, 35(5), 943-952.

    • Hsu, S. C., & Yen, T. H. (2021). Klotho-derived peptides in metabolic diseases: Therapeutic potential and molecular mechanisms. Diabetes & Metabolism, 47(1), 101199.