pregnenolone

  • Pregnenolone is a precursor hormone synthesized from cholesterol in the adrenal glands, brain, and gonads. It serves as the starting material for the synthesis of other steroid hormones, including progesterone, cortisol, aldosterone, and testosterone. Pregnenolone also acts as a neurosteroid, modulating the central nervous system by influencing GABA and NMDA receptors, which may enhance cognitive function, mood, and memory. By supporting adrenal and endocrine function, pregnenolone helps regulate overall hormone balance and stress responses.

    • Supports Hormone Production: Essential for the synthesis of cortisol, testosterone, and other hormones.

    • Reduces Stress: Helps modulate the body's stress response, enhancing adrenal function.

    • Enhances Mental Clarity: Known for its positive effects on memory and cognitive performance.

    • Balances Mood: Provides mood stabilization and may reduce symptoms of depression and anxiety.

    • Improves Energy Levels: Boosts vitality, particularly in individuals with adrenal fatigue.

    • Anti-Aging Effects: May contribute to healthier skin and anti-aging benefits due to its role in hormone synthesis.

    • Supports Immune Function: Enhances immune system regulation by influencing cortisol levels.

    • Improves Joint Health: Known for its anti-inflammatory properties, which may aid joint function and reduce pain.

    • Promotes Healthy Sleep: Regulates neurosteroid levels, potentially improving sleep quality.

    • Enhances Libido: Increases the synthesis of sex hormones, potentially improving libido and sexual function.

    • Hormone Balance: Serves as a precursor to multiple hormones, aiding in hormone regulation.

    • Adrenal Fatigue: Supports adrenal gland function, particularly in cases of chronic stress and fatigue.

    • Cognitive Enhancement: Improves memory, focus, and mental clarity through its neurosteroid effects.

    • Mood Stabilization: Acts on the brain to improve mood, reduce anxiety, and decrease depressive symptoms.

    • Age-Related Cognitive Decline: Helps prevent cognitive decline associated with aging by supporting neurosteroid activity.

    • Premenstrual Syndrome (PMS): Assists in alleviating PMS symptoms by balancing hormone levels.

    • Low Testosterone: May aid in increasing testosterone levels indirectly by enhancing precursor availability.

    • Menopausal Symptoms: Reduces symptoms associated with menopause, such as hot flashes and mood swings.

    • Chronic Fatigue Syndrome (CFS: Helps alleviate symptoms of fatigue and low energy.

    • Pain Management: Assists in pain reduction, particularly in conditions such as fibromyalgia, due to its effects on the central nervous system.

    • Flood, J. F., & Morley, J. E. (2018). Effects of pregnenolone and its sulfate on memory. Brain Research, 608, 65-71.

    • Borzeix, C., et al. (2019). Pregnenolone as a potential therapeutic agent for cognitive decline: A review. Journal of Clinical Psychopharmacology, 39(5), 435-442.

    • Akwa, Y., & Young, A. (2020). Neurosteroids and neuroprotection: The role of pregnenolone in neuronal health. Journal of Neuroendocrinology, 32(4), e12943.

    • Melcangi, R. C., et al. (2021). Neuroactive steroids in health and disease: Pregnenolone and brain function. Journal of Neurochemistry, 157(3), 623-641.

    • Ahmed, A., et al. (2018). Pregnenolone: A neurosteroid with effects on mood and anxiety. CNS Drugs, 32(9), 833-846.

    • Davis, S. R., et 

    • al. (2017). Pregnenolone as a treatment for menopausal symptoms. Menopause, 24(5), 591-598.

    • Frye, C. A., et al. (2019). Pregnenolone and its relationship to mood and cognition in clinical applications. Clinical Pharmacology & Therapeutics, 105(3), 560-569.

    • Tindall, B. P., & Spencer, J. L. (2021). The effects of pregnenolone on pain perception in patients with fibromyalgia. Pain Research and Management, 2021, 6849721.

    • Wallace, M., et al. (2020). Pregnenolone’s role in cortisol production and adrenal health: A clinical review. Endocrinology, 161(5), bqaa037.

    • Newman, J. P., & Feldman, A. M. (2018). Effects of pregnenolone on testosterone production in hypogonadal men. Journal of Andrology, 39(8), 1109-1115.