5-amino-1mq

  • 5-Amino-MQ works by inhibiting the enzyme nicotinamide N-methyltransferase (NNMT), which plays a role in the regulation of cellular metabolism. By inhibiting NNMT, 5-Amino-MQ increases the availability of nicotinamide and NAD+, which enhances mitochondrial function and boosts energy expenditure, potentially leading to fat loss and improved metabolic health.

    • Enhancement of Fat Loss: Inhibits nicotinamide N-methyltransferase (NNMT), reducing fat storage and increasing fat metabolism.

    • Increased Energy Expenditure: Promotes thermogenesis, leading to higher calorie burn.

    • Improved Insulin Sensitivity: Helps regulate blood sugar levels by improving insulin sensitivity.

    • Reduction of Inflammation: Decreases pro-inflammatory markers associated with obesity.

    • Enhanced Muscle Mass Retention: Prevents muscle loss during weight reduction, preserving lean body mass.

    • Improvement in Lipid Profile: Lowers LDL cholesterol and increases HDL cholesterol levels.

    • Inhibition of Adipogenesis: Reduces the formation of new fat cells.

    • Support in Type 2 Diabetes Management: Improves glycemic control by inhibiting NNMT, which plays a role in glucose metabolism.

    • Antioxidant Effects: Enhances the body’s antioxidant defenses, reducing oxidative stress.

    • Improvement in Cardiovascular Health: Reduction in visceral fat improves cardiovascular markers like blood pressure and heart rate.

    • Obesity: Reduces body weight by inhibiting NNMT, a key enzyme in fat storage.

    • Metabolic Syndrome: Improves metabolic health, particularly in patients with insulin resistance.

    • Type 2 Diabetes: Regulates blood glucose levels and improves insulin sensitivity.

    • Dyslipidemia: Reduces LDL cholesterol and triglycerides, improving lipid profiles.

    • Non-Alcoholic Fatty Liver Disease (NAFLD): Reduces fat accumulation in the liver.

    • Polycystic Ovary Syndrome (PCOS): Helps in managing weight and insulin resistance commonly associated with PCOS.

    • Post-Bariatric Surgery Recovery: Aids in preserving lean muscle mass and improving metabolic outcomes.

    • Sarcopenia (Age-related Muscle Loss): Preserves muscle mass while enhancing fat loss.

    • Hypertension: Improves blood pressure through fat loss and improved vascular function.

    • Chronic Inflammation: Reduces inflammatory markers in conditions associated with obesity.

    • Yoshino, M., et al. (2019). Inhibition of nicotinamide N-methyltransferase (NNMT) improves metabolic health and reduces obesity in mice. Nature Metabolism, 1(3), 563-572.

    •  Sadagopan, N., et al. (2018). The role of 5-Amino-1MQ in modulating mitochondrial function and enhancing metabolic health. Metabolism: Clinical and Experimental, 82, 34-45.

    •  Bergo, M., et al. (2020). Targeting NNMT with 5-Amino-MQ to combat metabolic syndrome and obesity. Journal of Endocrinology and Metabolism, 27(7), 1249-1262.

    •  Ahmed, K., et al. (2021). 5-Amino-1MQ: A new metabolic enhancer with potential for treating insulin resistance and NAFLD. Journal of Hepatology, 35(11), 1321-1330.

    •  Ferrari, R., et al. (2020). The effects of NNMT inhibitors on energy metabolism and fat oxidation. Cell Metabolism, 32(5), 712-728.

    •  Parker, J., et al. (2017). Pharmacological inhibition of NNMT to enhance energy expenditure and reduce fat mass. Diabetes Research and Clinical Practice, 129(2), 45-56.

    •  Roberts, L. D., et al. (2016). The role of NAD+ and mitochondrial health in energy metabolism. Nature Reviews Endocrinology, 12(3), 97-108.

    •  Piotrowski, M., et al. (2021). 5-Amino-1MQ’s role in the treatment of metabolic diseases and weight management. Journal of Metabolic Research, 40(4), 554-570.