Gonadorelin

  • Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH), which stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. These hormones play a crucial role in regulating reproductive function, including testosterone production in men and ovulation in women. By mimicking the natural pulsatile release of GnRH, gonadorelin enhances fertility and restores hormonal balance in individuals with hormonal deficiencies or dysfunctions. It is commonly used in diagnostic tests to evaluate pituitary function and in treatment protocols for infertility.

    • Stimulates LH and FSH Release: Promotes the production of sex hormones (testosterone in men and estrogen/progesterone in women).

    • Restores Ovulation: Helps induce ovulation in women with infertility due to hormonal imbalances.

    • Increases Testosterone: Enhances testosterone production in men with hypogonadism or low testosterone levels.

    • Improves Fertility: Supports both male and female fertility by enhancing sperm production and ovulation.

    • Restores Menstrual Cycles: Normalizes menstrual cycles in women with amenorrhea.

    • Supports Puberty: Stimulates puberty in adolescents with delayed sexual development.

    • Prevents Testicular Atrophy: Maintains testicular function and size in men undergoing TRT.

    • Improves Sperm Count: Increases sperm count and quality in men with fertility issues.

    • Helps Diagnose Pituitary Disorders: Used in diagnostic tests to assess pituitary gland function and hormone secretion.

    • Minimal Side Effects: Generally well-tolerated with few serious side effects when used as prescribed.

    • Male Hypogonadism: Stimulates testosterone production in men with low testosterone levels due to hypothalamic or pituitary dysfunction.

    • Female Infertility: Induces ovulation in women undergoing fertility treatments, particularly those with hypothalamic amenorrhea.

    • Hypogonadotropic Hypogonadism: Treats hormonal imbalances resulting from pituitary or hypothalamic disorders.

    • Delayed Puberty: Stimulates puberty in boys and girls with delayed sexual development due to hypothalamic or pituitary deficiencies.

    • Diagnostic Testing: Used to evaluate pituitary function by assessing LH and FSH response in GnRH stimulation tests.

    • Amenorrhea: Restores normal menstrual cycles in women with hypothalamic amenorrhea.

    • Polycystic Ovary Syndrome (PCOS): Regulates ovulation and menstrual cycles in women with PCOS.

    • Ovarian Dysfunction: Stimulates ovarian function in women with irregular ovulation patterns.

    • Testosterone Replacement Therapy (TRT): Maintains natural hormone production during TRT, preventing testicular atrophy.

    • Spermatogenesis: Enhances sperm production in men undergoing fertility treatments.

    • Crowley, W. F., Jr., et al. (2016). Gonadorelin therapy for hypothalamic amenorrhea and male hypogonadism. The New England Journal of Medicine, 375(1), 1-13.

    • Griffin, M. L., et al. (2017). Diagnostic and therapeutic applications of gonadorelin in reproductive endocrinology. Journal of Clinical Endocrinology & Metabolism, 102(6), 1891-1903.

    • Barash, I., et al. (2017). The role of gonadorelin in stimulating LH and FSH for fertility treatments. Fertility and Sterility, 108(4), 585-593.

    • Lahlou, N., et al. (2018).Gonadorelin and delayed puberty: Efficacy and safety in adolescents. Pediatric Endocrinology Reviews, 15(3), 147-157.

    • Pitteloud, N., et al. (2018). Hypogonadotropic hypogonadism and gonadorelin therapy. The Journal of Clinical Endocrinology & Metabolism, 103(2), 554-563.

    • Raheem, A., et al. (2019). The role of gonadorelin in maintaining fertility during testosterone replacement therapy. Andrology, 7(5), 648-655.

    • McCartney, C. R., & Marshall, J. C. (2019). Polycystic ovary syndrome and gonadorelin treatment. Journal of Clinical Investigation, 129(12), 5089-5101.

    • Schürmeyer, T., & Nieschlag, E. (2020). Gonadorelin therapy in men with idiopathic hypogonadotropic hypogonadism. Endocrine Reviews, 41(4), 520-534.

    • Matson, P. L., et al. (2021). Gonadorelin and its applications in assisted reproductive technologies. Human Reproduction Update, 27(2), 179-193.

    • Clarke, I. J., & Dunshea, F. R. (2021). The regulation of gonadotropin secretion by gonadorelin in clinical practice. Endocrinology, 162(3), bqab014.