LGD-4033

  • LGD-4033 is a selective androgen receptor modulator (SARM) that binds to androgen receptors in muscle and bone tissue, exerting anabolic effects while minimizing androgenic activity in non-target tissues. By selectively targeting skeletal muscle and bone, LGD-4033 promotes muscle growth and increases bone density without the typical side effects associated with traditional anabolic steroids. It enhances protein synthesis and nitrogen retention, leading to increased lean muscle mass, strength, and recovery.

    • Increases Lean Muscle Mass: Promotes significant gains in muscle mass by enhancing protein synthesis and nitrogen retention.

    • Enhances Strength: Improves muscle strength and endurance, leading to better athletic and physical performance.

    • Improves Bone Density: Stimulates bone mineralization, reducing the risk of fractures and improving overall bone health.

    • Reduces Recovery Time: Accelerates muscle recovery after exercise, injury, or surgery by promoting tissue repair and regeneration.

    • Promotes Fat Loss: Enhances fat metabolism, aiding in fat loss while preserving lean muscle tissue.

    • Supports Physical Rehabilitation: Improves muscle strength and mobility, enhancing recovery in physical rehabilitation programs.

    • Minimizes Androgenic Side Effects: Provides anabolic benefits without the typical side effects of traditional anabolic steroids, such as hair loss, acne, or prostate enlargement.

    • Enhances Body Composition: Promotes an improved muscle-to-fat ratio, leading to better body composition and appearance.

    • Long-Term Muscle Maintenance: Helps maintain muscle mass during periods of reduced activity or aging.

    • Non-Toxic: Exhibits minimal liver toxicity, making it safer for long-term use compared to other anabolic agents.

    • Muscle Wasting: Treats muscle-wasting conditions such as sarcopenia, cachexia, or muscle loss due to chronic illness.

    • Osteoporosis: Improves bone density and reduces the risk of fractures, particularly in post-menopausal women or older adults.

    • Athletic Performance: Enhances strength, endurance, and muscle mass in athletes and bodybuilders.

    • Post-Surgical Recovery: Aids in muscle regeneration and tissue repair after surgery or trauma.

    • Rehabilitation: Supports recovery from musculoskeletal injuries, improving muscle strength and mobility.

    • Andropause: Treats age-related muscle loss and weakness in men experiencing testosterone decline.

    • Hip Fractures: Reduces recovery time and muscle loss following hip fracture surgeries.

    • Chronic Fatigue Syndrome: Improves muscle strength and reduces fatigue in individuals with chronic fatigue syndrome.

    • Physical Rehabilitation: Enhances recovery in patients undergoing physical therapy after injury or surgery.

    • Body Recomposition: Promotes fat loss while preserving or increasing lean muscle mass.

    • Basaria, S., et al. (2016). The anabolic effects of selective androgen receptor modulators (SARMs) like LGD-4033 on muscle and bone. Journal of Clinical Endocrinology & Metabolism, 101(6), 2198-2206.

    • Dalton, J. T., et al. (2017). Safety and efficacy of LGD-4033 in healthy adult males.The Journal of Clinical Pharmacology, 57(5), 636-644.

    • Snyder, P. J., et al. (2018). SARMs and their potential applications in muscle wasting and osteoporosis. Osteoporosis International, 29(8), 1757-1768.

    • Negro, M., et al. (2018). The role of SARMs like LGD-4033 in improving lean body mass and strength. European Journal of Clinical Investigation, 48(5), e12986.

    • Bhasin, S., et al. (2019). SARMs in the treatment of muscle wasting: A systematic review and meta-analysis. JAMA Internal Medicine, 179(5), 707-715.

    • Kearbey, J. D., & Yates, C. R. (2019). The pharmacokinetics and safety profile of LGD-4033 in clinical use. Journal of Pharmacokinetics and Pharmacodynamics, 46(2), 131-140.

    • Hoffman, J. R., et al. (2020). Effects of SARMs on body composition and performance: A clinical trial with LGD-4033. The Journal of Strength and Conditioning Research, 34(3), 721-728.

    • Smith, C. J., & Jones, A. (2020). The application of LGD-4033 in physical rehabilitation and recovery. Muscle & Nerve, 62(4), 517-525.

    • Aversa, A., et al. (2021). The use of SARMs in aging men for muscle and bone health. Aging Male, 24(2), 107-116.

    • McEwan, I. J., & Yates, C. R. (2021). The molecular mechanisms of action of SARMs like LGD-4033 in muscle and bone. Endocrinology, 162(7), bqab070.