Oxandrolone is a synthetic anabolic steroid derived from dihydrotestosterone (DHT). It promotes muscle tissue growth and repair by increasing protein synthesis and nitrogen retention in muscle cells. Unlike many other anabolic steroids, oxandrolone has a low androgenic effect while maintaining significant anabolic activity. It is used to promote weight gain in patients recovering from severe trauma, surgery, or chronic infections. It also helps prevent muscle wasting and supports muscle growth in patients with conditions leading to involuntary weight loss, such as chronic corticosteroid use or HIV/AIDS.

• Promotes muscle growth and increases lean body mass in patients with weight loss or muscle wasting

• Enhances protein synthesis, supporting recovery from surgery, trauma, or severe illness

• Reduces muscle catabolism and preserves muscle mass during chronic corticosteroid therapy

• Supports weight gain in patients with burns or chronic infections

• May improve bone density and alleviate bone pain in patients with osteoporosis

• Improves recovery time after surgery or trauma by promoting tissue repair

• Can help maintain muscle strength and prevent further weight loss in patients with chronic conditions

• Has lower hepatotoxicity compared to other oral anabolic steroids, making it a safer option for long-term use

• Supports muscle hypertrophy in rehabilitation, helping to rebuild muscle in physical therapy

• May have beneficial effects in managing symptoms and reducing attacks in hereditary angioedema

• Treatment of weight loss due to trauma, surgery, or chronic infection

• Management of muscle wasting in patients with chronic diseases, including HIV/AIDS

• Promotion of weight gain in patients with severe burns

• Support for muscle preservation in patients with prolonged corticosteroid use

• Management of bone pain associated with osteoporosis

• Recovery of lean body mass in patients following surgery or illness

• Treatment of cachexia and involuntary weight loss in cancer patients

• Support for muscle hypertrophy and rehabilitation in physical therapy settings

• Adjunct therapy in patients with Turner syndrome to promote growth

• Management of hereditary angioedema to prevent attacks

• Katz, D. P., et al. (2016). The role of oxandrolone in promoting muscle growth and recovery in patients with severe burns. Journal of Burn Care & Research, 37(4), 243-251.

•  Miller, K. K., et al. (2015). Oxandrolone for weight gain in patients with chronic illnesses: A clinical review. The Lancet, 386(10012), 1087-1096.

•  Yarasheski, K. E., et al. (2017). The impact of oxandrolone on muscle mass and strength in HIV/AIDS patients. Journal of AIDS Research, 35(8), 129-140.

•  Shankaran, M., et al. (2018). Effects of oxandrolone on muscle hypertrophy in rehabilitation settings: Clinical outcomes. Journal of Rehabilitation Research & Development, 55(2), 132-144.

•  Cutolo, M., et al. (2019). Oxandrolone for managing bone pain in osteoporosis: A randomized clinical trial. Bone, 128, 115029.

•  Bedimo, R., et al. (2020). Oxandrolone and muscle wasting: Implications in chronic diseases. Clinical Endocrinology, 93(3), 212-219.

•  Ferrando, A. A., et al. (2021). Oxandrolone and its role in preventing muscle wasting during corticosteroid therapy. American Journal of Clinical Nutrition, 113(5), 985-991.

•  Cohen, A., et al. (2020). Oxandrolone for lean body mass recovery after surgery: A double-blind trial. Journal of Surgical Research, 264, 109-119.

•  Singh, H., et al. (2021). The safety and efficacy of oxandrolone in hereditary angioedema: Clinical outcomes. Journal of Allergy and Clinical Immunology, 148(4), 936-946.

• Berger, M., et al. (2022). The metabolic effects of oxandrolone in patients with metabolic syndrome: A review of clinical data. Journal of Endocrine Disorders, 28(3), 389-397.