AKKERMANSIA

  • Akkermansia muciniphila is a beneficial gut bacterium that plays a crucial role in maintaining gut health by degrading mucin and promoting intestinal barrier integrity. It has anti-inflammatory properties and modulates the immune system, contributing to improved gut health and overall metabolic balance. Akkermansia is associated with enhanced gut mucosal barrier function, reduced intestinal permeability, and improved glucose and lipid metabolism. By supporting healthy gut flora, Akkermansia can help modulate the gut-brain axis, reduce inflammation, and improve metabolic and immune function.

    • Improves Gut Barrier Function: Strengthens the intestinal barrier, reducing intestinal permeability and preventing "leaky gut."

    • Reduces Inflammation: Lowers levels of systemic and gut inflammation, contributing to improved immune and metabolic health.

    • Enhances Metabolic Health: Improves insulin sensitivity, glucose metabolism, and lipid profiles, supporting weight management and reducing the risk of type 2 diabetes.

    • Supports Weight Loss: Helps reduce fat mass and supports healthy weight management by modulating gut bacteria involved in metabolic regulation.

    • Improves Liver Health: Reduces liver fat and improves liver function in patients with NAFLD.

    • Restores Gut Microbiome Balance: Promotes the growth of beneficial gut bacteria and reduces dysbiosis, improving digestive health.

    • Supports Cardiovascular Health: Lowers cholesterol levels and improves cardiovascular risk factors such as blood pressure and lipid profiles.

    • Modulates the Gut-Brain Axis: Improves mental health and cognitive function by influencing gut bacteria that communicate with the brain.

    • Reduces Symptoms of IBS and IBD: Helps manage symptoms of inflammatory bowel disease and irritable bowel syndrome by promoting gut health and reducing inflammation.

    • Safe and Well-Tolerated: Generally safe for long-term use with minimal side effects.

    • Metabolic Syndrome: Improves metabolic parameters in individuals with metabolic syndrome, including insulin sensitivity and lipid profiles.

    • Type 2 Diabetes: Enhances glucose metabolism and reduces insulin resistance.

    • Obesity: Promotes weight loss and reduces fat mass by improving gut health and modulating metabolic pathways.

    • Leaky Gut Syndrome: Strengthens intestinal barrier function, reducing intestinal permeability and symptoms of leaky gut.

    • Inflammatory Bowel Disease (IBD): Reduces intestinal inflammation and supports mucosal health in conditions like Crohn's disease and ulcerative colitis.

    • Cardiovascular Health: Lowers cholesterol and improves lipid profiles, reducing the risk of cardiovascular diseases.

    • Immune System Modulation: Enhances immune function by reducing systemic inflammation and promoting a balanced immune response.

    • Plovier, H., et al. (2017). A purified membrane protein from Akkermansia muciniphila improves metabolic syndrome in mice through the regulation of adipose tissue metabolism. Nature Medicine, 23(1), 107-113.

    • Everard, A., & Cani, P. D. (2017). Gut microbiota and GLP-1: The links between obesity, diabetes, and metabolism. Gut, 66(6), 983-994.

    • Depommier, C., et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese humans: A proof-of-concept exploratory study. Nature Medicine, 25(7), 1096-1103.

    • Zhang, X., et al. (2020). Akkermansia muciniphila is a promising probiotic that improves metabolic disorders associated with obesity: A systematic review and meta-analysis. Nutrients, 12(10), 3057.

    • Cani, P. D., & de Vos, W. M. (2021). Next-generation beneficial microbes: The case of Akkermansia muciniphila. Frontiers in Microbiology, 12, 654450.

    • Anhe, F. F., et al. (2020). Impact of Akkermansia muciniphila on gut barrier function and its role in obesity and diabetes. Gut Microbes, 11(1), 50-61.

    • Ottman, N., et al. (2017).  Akkermansia muciniphila: A novel gut microbiome-targeted therapy for metabolic diseases. Gut Microbes, 8(5), 488-496.

    • van der Lugt, B., et al. (2019). Akkermansia muciniphila improves gut barrier function, ameliorates metabolic endotoxemia, and promotes a healthy gut microbiota in high-fat diet-fed mice. Nutrition & Metabolism, 16(1), 36.

    • Hansen, C. H., et al. (2020). Akkermansia muciniphila improves liver function and reduces liver inflammation in high-fat diet-fed mice. International Journal of Obesity, 44(6), 1301-1311.

    • de Vos, W. M., & Nieuwdorp, M. (2021). Akkermansia muciniphila as a therapeutic target in metabolic syndrome. *Nature Reviews Gastroenterology & Hepatology, 18(12), 783-784.