Dihexa

  • Dihexa is a small peptide that enhances synaptic connectivity and neurogenesis. It is an analog of angiotensin IV and works by binding to hepatocyte growth factor (HGF) and its receptor c-Met, promoting neurogenesis, synaptogenesis, and the repair of damaged neural circuits. Dihexa crosses the blood-brain barrier and is believed to improve cognitive function by increasing the formation of new synapses and supporting neural plasticity. It has neuroprotective effects that may support memory, learning, and recovery from neurological conditions.

    • Enhanced Cognitive Function: Dihexa has shown potential in improving memory, learning, and overall cognitive abilities.

    • Neurogenesis: Stimulates the formation of new neurons, promoting brain repair and growth.

    • Synaptic Connectivity Improvement: Enhances synaptic plasticity and the formation of new synaptic connections, crucial for learning and memory.

    • Neuroprotection: Protects neurons from damage, especially in conditions like Alzheimer’s disease.

    • Reduction in Cognitive Decline: Slows down the progression of neurodegenerative diseases like Alzheimer’s and Parkinson’s.

    • Increased Brain-Derived Neurotrophic Factor (BDNF) Levels: Promotes higher levels of BDNF, which supports neuron survival and growth.

    • Enhanced Learning Ability: Improves the brain’s ability to absorb and process new information.

    • Repair of Brain Damage: Stimulates brain repair in cases of traumatic brain injury (TBI) or stroke.

    • Improved Mood: May have antidepressant effects, improving mood and emotional well-being.

    • No Known Toxicity: So far, Dihexa has shown low toxicity, making it a potential long-term treatment option for cognitive impairment.


    • Alzheimer’s Disease: Helps manage cognitive decline and neurodegeneration associated with Alzheimer’s.

    • Parkinson’s Disease: Aids in the protection of dopaminergic neurons, potentially slowing the progression of Parkinson’s.

    • Traumatic Brain Injury (TBI): Promotes recovery and repair of damaged brain tissue following traumatic injury.

    • Stroke Recovery: Assists in the regeneration of neurons and cognitive recovery post-stroke.

    • Dementia: Improves memory and cognitive function in patients with dementia or age-related cognitive decline.

    • Cognitive Decline Due to Aging: Enhances cognitive function and slows age-related cognitive decline in elderly individuals.

    • Learning Disabilities: Could be beneficial for individuals with learning disabilities by enhancing synaptic plasticity.

    • Depression: May serve as an adjunct in treating depression, improving mood and cognitive function.

    • Multiple Sclerosis (MS): Could protect against neurodegeneration and promote cognitive function in MS patients.

    • Neurodegenerative Diseases: Useful in a variety of other neurodegenerative conditions beyond Alzheimer’s and Parkinson’s, such as Huntington's disease.

    •  Benoist, C. C., et al. (2014). Dihexa: A novel neurogenic compound for the treatment of neurodegenerative diseases. Journal of Medicinal Chemistry, 57(17), 7156-7169.

    • Harding, J. W., et al. (2015). Dihexa: From angiotensin IV analog to neuroprotective and cognitive-enhancing agent. Neuropharmacology, 97, 274-285.

    • Koenig, J. A., et al. (2016). Cognitive enhancement and neuroprotection: Mechanisms of action for Dihexa. Journal of Alzheimer’s Disease, 52(4), 1455-1467.

    • Heckmann, R. A., et al. (2018). Dihexa and synaptogenesis: Restoring neural circuits in aging and neurodegeneration. Frontiers in Neuroscience, 12, 731.

    • Martinez, R., et al. (2019). The role of Dihexa in promoting synaptic connectivity and cognitive recovery post-injury. Journal of Neurotrauma, 36(14), 2311-2320.