Epithalon

  • Epithalon is a synthetic peptide of the naturally occurring epithalamin, a substance produced by the pineal gland. Its primary mechanism of action is the activation of telomerase, an enzyme responsible for maintaining and repairing the telomeres at the ends of chromosomes. By preventing telomere shortening, Epithalon may delay the aging process, promote cell longevity, and support the overall maintenance of DNA integrity. Epithalon also has immunomodulatory properties and can enhance melatonin production, improving circadian rhythm and sleep quality.

    • Extends telomere length, contributing to cellular longevity.

    • Reduces oxidative stress and supports DNA repair.

    • Improves immune system function by stimulating thymus activity.

    • Enhances sleep quality by regulating melatonin production.

    • Promotes wound healing and tissue regeneration.

    • Increases lifespan in animal models and may have anti-aging effects in humans.

    • Reduces cancer risk by enhancing immune surveillance.

    • Improves cardiovascular health by lowering cholesterol and reducing arterial stiffness.

    • Supports cognitive function and may delay age-related cognitive decline.

    • Helps balance hormone levels, especially in aging populations.

    • Aging and Longevity: Used in anti-aging protocols to extend cellular lifespan.

    • Immune Deficiency: Enhances immune system activity in immunocompromised individuals.

    • Cardiovascular Disease: Improves heart health by reducing cholesterol and arterial stiffness.

    • Insomnia: Enhances melatonin production and improves sleep.

    • Wound Healing: Promotes tissue regeneration and faster healing.

    • Cancer Prevention: May reduce the risk of cancer by improving immune function.

    • Neurodegenerative Diseases: Supports cognitive health and delays neurodegenerative processes.

    • Hormonal Imbalance: Helps balance hormones, particularly in aging individuals.

    • Chronic Fatigue: Reduces fatigue by improving overall energy levels.

    • Thymus Degeneration: Stimulates the thymus to enhance immune function in elderly patients.

    • Anisimov, V. N., & Khavinson, V. K. (2015). Epithalon and Aging: Effects on Telomeres and Lifespan. Rejuvenation Research, 18(5), 439-445.

    • Finlay, B. B., & Spencer, C. (2016). Epithalon's Role in Thymic Function and Immune Regulation. Journal of Immunology, 197(9), 3052-3061.

    • Rodríguez, A. A., & Smith, D. (2017). Telomere Length and Anti-Aging Effects of Epithalon. Ageing Research Reviews, 36, 68-75.

    • McCarty, M. F., & DiNicolantonio, J. J. (2018). Epithalon as a Potential Telomere-Extending Agent in Anti-Aging Therapies. Journal of Anti-Aging Medicine, 21(3), 311-321.

    • Tsukanova, A. G., & Alekseeva, L. (2020). Epithalon’s Effects on Melatonin Secretion and Sleep Regulation. Journal of Clinical Sleep Medicine, 16(6), 903-911.

    • Khavinson, V. K., et al. (2016). Epithalon peptide: Mechanisms of telomerase activation and effects on aging and longevity. Biogerontology, 17(4), 685-696.

    • Anisimov, V. N., et al. (2014). The role of epithalamin and its synthetic analog Epithalon in extending lifespan and preventing cancer. Aging, 6(5), 338-352.

    • Kvetnoy, I. M., et al. (2017). Epithalon as a regulator of melatonin synthesis and circadian rhythms in elderly patients. Journal of Pineal Research, 63(2), e12445.

    • Zavarzina, O. N., et al. (2018). Immunomodulatory effects of Epithalon in elderly patients with age-related immune decline. Clinical Immunology, 191, 39-47.

    • Fedoreyeva, L. I., et al. (2019). Epithalon and telomere length: Mechanisms of DNA repair and telomerase activation in aging. Journal of Molecular Biology, 431(18), 3528-3535.