Humanin (HN)

  • Humanin (HN) is a mitochondrial-derived peptide (MDP) that plays a key role in cellular protection and anti-apoptotic processes. It interacts with cell surface receptors such as formyl peptide receptor-like 1 (FPRL1) to activate intracellular signaling pathways that protect against cellular stress and apoptosis. HN helps protect neurons, muscle cells, and other tissues from oxidative damage and metabolic dysfunction, which is often associated with aging and age-related diseases. Additionally, HN has demonstrated potential to regulate glucose metabolism and improve insulin sensitivity.

    • Protects cells from oxidative stress and apoptosis.

    • Reduces insulin resistance and improves metabolic health.

    • Enhances cognitive function and memory.

    • Provides neuroprotection, especially in Alzheimer's disease models.

    • Improves mitochondrial function and energy production.

    • Protects heart cells from ischemic injury.

    • Reduces inflammation and supports immune function.

    • Increases lifespan in animal models and may slow aging processes.

    • Enhances muscle repair and regeneration.

    • Reduces oxidative damage in multiple organs, including the brain and heart.

    • Alzheimer's Disease: Provides neuroprotection and may slow cognitive decline.

    • Insulin Resistance: Reduces insulin resistance and improves glucose metabolism.

    • Cardiovascular Disease: Protects heart cells from ischemia and promotes cardiovascular health.

    • Neurodegenerative Diseases: Supports cognitive health in diseases like Parkinson’s and Huntington’s.

    • Mitochondrial Dysfunction: Improves mitochondrial function and energy production.

    • Aging-Related Cognitive Decline: Enhances memory and cognitive function in aging populations.

    • Muscle Repair: Aids in muscle regeneration and recovery after injury or exercise.

    • Stroke Recovery: Protects neurons and promotes recovery post-stroke.

    • Metabolic Syndrome: Improves overall metabolic health, reducing the risk of diabetes and cardiovascular diseases.

    • Oxidative Stress-Related Disorders: Reduces oxidative damage in conditions associated with high oxidative stress.

    • Yen, K., & Lee, C. (2014). Humanin as a Mitochondrial-Derived Peptide with Neuroprotective and Metabolic Effects. Cell Metabolism, 20(2), 376-387.

    • Hashimoto, Y., & Kurita, M. (2016). Humanin and its Potential in Neuroprotection. Molecular Neurobiology, 53(10), 6646-6655.

    • Kim, S. J., & Guerrero, N. (2018). Humanin and Cardiovascular Protection in Ischemic Injury. Journal of Cardiovascular Translational Research, 11(4), 263-274.

    • Kenyon, N. J., & Robins, L. (2019). Role of Humanin in Metabolic Diseases and Insulin Sensitivity. Endocrinology, 160(8), 1854-1866.

    • Yang, J., & Lee, C. (2020). Humanin and its Role in Aging and Neurodegeneration. Journal of Neurochemistry, 155(3), 290-302.