IGF-1

  • IGF-1 is a peptide hormone structurally similar to insulin and plays a crucial role in growth and development. It is primarily produced in the liver in response to growth hormone (GH) stimulation and mediates many of the anabolic effects of GH. IGF-1 promotes cellular growth, differentiation, and survival by binding to its receptor (IGF1R) and activating intracellular signaling pathways, including the PI3K-AKT and MAPK pathways. These pathways are responsible for protein synthesis, cell proliferation, and inhibition of apoptosis. IGF-1 is essential for muscle growth, bone density maintenance, and overall metabolic regulation.

    • Promotes muscle growth and regeneration.

    • Enhances bone density and supports skeletal health.

    • Stimulates protein synthesis, aiding in recovery after exercise.

    • Reduces fat mass and promotes lean body mass development.

    • Supports cognitive function and may improve learning and memory.

    • Enhances tissue repair and wound healing.

    • Protects neurons from oxidative damage, offering neuroprotection.

    • Improves skin elasticity and reduces signs of aging.

    • Increases energy and vitality by improving metabolic function.

    • Supports cardiovascular health by improving vascular function.

    • Growth Hormone Deficiency: Treats children and adults with growth hormone deficiencies.

    • Muscle Wasting Disorders: Enhances muscle growth in conditions like sarcopenia or cachexia.

    • Bone Fragility: Improves bone density and reduces the risk of osteoporosis.

    • Traumatic Brain Injury: Supports cognitive recovery and neuroprotection after injury.

    • Wound Healing: Enhances tissue repair and accelerates recovery post-surgery or injury.

    • Athletic Performance: Promotes muscle growth, recovery, and fat loss in athletes.

    • Cognitive Decline: May improve cognitive function and slow age-related decline.

    • Post-Surgical Recovery: Enhances healing and tissue regeneration after surgery.

    • Aging: Used in anti-aging protocols to promote vitality and muscle health.

    • Heart Disease: Improves cardiovascular function and reduces the risk of heart disease.

    • Clemmons, D. R. (2015). Role of IGF-I in the regulation of human growth: Therapeutic implications. Nature Reviews Endocrinology, 11(6), 349-362.

    •  O’Neill, B. T., et al. (2016). Insulin and IGF-1 action in the brain: A lifespan perspective. Nature Reviews Endocrinology, 12(3), 174-182.

    •  Friedrichsen, M., et al. (2017). The role of IGF-1 in muscle hypertrophy and repair. Frontiers in Endocrinology, 8, 27.

    •  LeRoith, D., et al. (2019). IGF-1 and its role in neuroprotection and brain function. Journal of Neuroscience Research, 97(4), 513-523.

    •  Philippou, A., et al. (2018). Mechanisms of action of IGF-1 in muscle repair and regeneration. BioMed Research International, 2018, 1-9.

    •  Laron, Z., et al. (2016). IGF-1 deficiency: Lessons from the Laron syndrome. Nature Reviews Endocrinology, 12(1), 37-48.

    •  Velloso, C. P. (2020). Regulation of muscle growth and insulin-like growth factor 1. Journal of Endocrinology, 245(2), R1-R20.

    •  Rabinovsky, E. D. (2017). IGF-1 and exercise: Molecular pathways associated with muscle hypertrophy. International Journal of Sports Medicine, 38(1), 38-45.

    •  Russo, V. C., et al. (2018). The role of IGF-1 and IGF-1 receptors in disease and aging. Journal of Gerontology, 73(6), 937-949.

    •  Delafontaine, P., et al. (2019). Cardiovascular benefits of IGF-1. Cardiovascular Research, 115(5), 949-960.