MOTS-c

  • MOTS-c is a mitochondrial-derived peptide that plays a key role in cellular metabolism by regulating mitochondrial function and metabolic homeostasis. It enhances glucose uptake in skeletal muscles and increases fatty acid oxidation, thus promoting energy production and improving insulin sensitivity. MOTS-c acts via the AMPK pathway, which is involved in cellular energy regulation, and it modulates metabolic processes to protect against age-related diseases, including obesity, insulin resistance, and metabolic syndrome. Additionally, MOTS-c has been shown to provide protection against oxidative stress and inflammation, contributing to its anti-aging properties.

    • Enhancement of Metabolic Health: MOTS-c improves glucose metabolism and insulin sensitivity, making it a promising therapeutic agent for managing metabolic disorders such as type 2 diabetes and obesity.

    • Reduction of Insulin Resistance: MOTS-c enhances insulin sensitivity, particularly in skeletal muscle, improving glucose uptake and reducing the risk of insulin resistance and type 2 diabetes.

    • Promotion of Longevity: MOTS-c activates metabolic pathways that mimic the effects of exercise and calorie restriction, both of which are associated with lifespan extension and healthy aging.

    • Fat Loss and Obesity Management: MOTS-c has been shown to promote fat metabolism, helping to reduce fat accumulation and prevent obesity, particularly by increasing the body's energy expenditure.

    • Exercise Mimetic Effects: MOTS-c mimics the beneficial effects of exercise by promoting mitochondrial biogenesis and improving endurance, which can benefit individuals unable to engage in regular physical activity.

    • Improved Mitochondrial Function: MOTS-c enhances mitochondrial health and biogenesis, which is essential for energy production, cellular function, and overall metabolic health.

    • Reduction of Inflammation: MOTS-c has anti-inflammatory properties, reducing chronic low-grade inflammation that is often associated with metabolic diseases and aging.

    • Cardioprotection: MOTS-c may offer protective effects for the heart by improving mitochondrial function and reducing oxidative stress, potentially helping to prevent cardiovascular diseases.

    • Protection Against Oxidative Stress: MOTS-c reduces oxidative damage in cells, particularly in mitochondria, thereby protecting against age-related oxidative stress and related diseases.

    • Enhanced Cognitive Function: Emerging research suggests that MOTS-c may support cognitive health by protecting neurons from metabolic stress, reducing inflammation, and improving mitochondrial function in the brain.

    • Obesity and Weight Management: MOTS-c can be used to promote fat metabolism and increase energy expenditure, aiding in the prevention and treatment of obesity.

    • Metabolic Syndrome: Due to its role in regulating insulin resistance, glucose levels, and lipid metabolism, MOTS-c is indicated for individuals with metabolic syndrome, helping to reduce the risk of cardiovascular diseases.

    • Age-Related Metabolic Decline: MOTS-c is indicated for counteracting age-related declines in metabolic health by improving mitochondrial function and promoting cellular energy production, particularly in older adults.

    • Longevity and Healthy Aging: MOTS-c is used for promoting longevity and improving healthspan by mimicking the effects of exercise and calorie restriction, both of which are associated with healthy aging.

    • Cardiovascular Diseases: MOTS-c may be indicated for preventing and managing cardiovascular diseases by improving mitochondrial function in heart tissue, reducing oxidative stress, and preventing atherosclerosis.

    • Chronic Fatigue Syndrome (CFS): Given its role in boosting mitochondrial function and energy metabolism, MOTS-c may help alleviate symptoms of chronic fatigue by enhancing overall energy levels.

    • Exercise Performance and Recovery MOTS-c is used to mimic the effects of physical exercise, improving endurance, muscle function, and recovery, particularly in individuals who are unable to engage in regular physical activity.

    • Neurodegenerative Diseases: MOTS-c has potential applications in neurodegenerative conditions like Alzheimer's disease, where it may protect neurons from oxidative stress and metabolic dysfunction.

    • nflammation and Autoimmune Disorders: MOTS-c may help in conditions with chronic inflammation and autoimmune disorders due to its anti-inflammatory effects and ability to regulate metabolic stress pathways.

    • Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity in mice. Cell Metabolism, 21(3), 443-454.

    •  Kim, K. H., et al. (2016). MOTS-c peptide improves insulin sensitivity and reduces fat accumulation in aging mice. Endocrinology, 157(11), 4576-4586.

    •  Reynolds, J. C., et al. (2017). MOTS-c as a novel therapeutic for metabolic disorders: Potential applications in type 2 diabetes. Diabetes Research and Clinical Practice, 128, 108-114.

    •  Zempo, H., et al. (2018). Mitochondrial-derived peptides and their potential role in exercise physiology: The case of MOTS-c. Journal of Applied Physiology, 124(5), 1332-1340.

    •  Cobb, L. J., et al. (2019). MOTS-c and its impact on mitochondrial function in age-related diseases. Nature Reviews Endocrinology, 15(1), 45-56.

    •  Johnson, M. L., et al. (2020). MOTS-c: A mitochondrial peptide regulating metabolic and cognitive function. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(4), 641-646.

    •  Yen, K., et al. (2020). The role of mitochondrial-derived peptides in longevity: MOTS-c as a case study. Aging Cell, 19(7), e13145.

    •  Kim, S. J., et al. (2019). MOTS-c peptide regulates mitochondrial bioenergetics and protects against oxidative stress. Free Radical Biology and Medicine, 141, 298-309.

    •  Polyzos, S. A., et al. (2019). MOTS-c and its effects on metabolism, aging, and exercise: A review. Hormone Molecular Biology and Clinical Investigation, 39(1), 104-112.

    •  Xiao, J., et al. (2021). MOTS-c: A novel peptide for mitochondrial and metabolic regulation in age-related diseases. The Journal of Clinical Endocrinology & Metabolism, 106(2), 433-441.