PEG- MGF

  • PEG-MGF is a modified version of Mechano Growth Factor (MGF), which is a splice variant of Insulin-like Growth Factor 1 (IGF-1). MGF is produced in muscle tissue in response to mechanical stress or damage, such as exercise or injury, and promotes muscle repair, regeneration, and growth. PEGylation extends the half-life of MGF, allowing it to remain in circulation longer and increasing its therapeutic effectiveness. PEG-MGF stimulates the proliferation of satellite cells (muscle stem cells), enhances protein synthesis, and accelerates muscle recovery, repair, and hypertrophy. It also promotes tissue regeneration in other parts of the body, such as tendons and bones.

    • Growth Hormone Deficiency: MK-677 is indicated for patients with growth hormone deficiency due to its ability to stimulate endogenous GH and IGF-1 production without the need for exogenous hormone administration.

    • Muscle Wasting (Cachexia): MK-677 can be used to treat muscle wasting in conditions such as cancer, HIV/AIDS, or chronic diseases where maintaining lean muscle mass is critical for patient outcomes.

    • Sarcopenia (Age-Related Muscle Loss) In older adults, MK-677 helps increase muscle mass and strength, making it useful for combating sarcopenia and improving physical function and quality of life in aging populations.

    • Osteoporosis and Bone Density Disorders: MK-677 is indicated for improving bone mineral density, making it a therapeutic option for individuals with osteoporosis or those at risk of bone fractures, especially postmenopausal women.

    • Obesity and Metabolic Syndrome: By enhancing fat metabolism and improving insulin sensitivity, MK-677 may be indicated for treating obesity and metabolic syndrome, particularly when diet and exercise are insufficient.

    • Sleep Disorders: MK-677 can be used to improve sleep quality, particularly in individuals suffering from poor REM sleep or insomnia, as it enhances deep sleep stages, which are important for recovery and cognitive function.

    • Recovery from Injury or Surgery: MK-677 may aid in the recovery process following surgery or trauma by promoting tissue repair and speeding up the healing process due to its anabolic effects on muscle and tissue regeneration.

    • Anorexia and Appetite Stimulation: MK-677 is indicated for conditions like anorexia or other eating disorders where increasing appetite and caloric intake is necessary to maintain body weight and overall health.

    • Chronic Fatigue Syndrome (CFS): MK-677 may be used to help manage symptoms of chronic fatigue by improving sleep quality, enhancing recovery, and promoting a sense of well-being, which is often compromised in CFS patients.

    • Hypopituitarism: For patients with hypopituitarism (underactive pituitary gland), MK-677 can stimulate the production of growth hormone and IGF-1, providing a non-invasive treatment option for hormone deficiencies associated with this condition.

    • Muscle Injury Recovery: Enhances muscle repair following trauma or injury.

    • Muscle Atrophy: Prevents muscle wasting during periods of inactivity or illness.

    • Sarcopenia: Used in age-related muscle loss to promote muscle regeneration.

    • Athletic Performance: Enhances recovery and muscle growth in athletes.

    • Tendon and Ligament Injuries: Promotes repair of tendons and ligaments after injury.

    • Bone Fractures: Supports skeletal repair and bone density improvement.

    • Post-Surgical Recovery: Enhances tissue regeneration after surgical interventions.

    • Chronic Wounds: Improves wound healing and reduces scar formation.

    • Burn Recovery: Promotes tissue repair in burn victims.

    • Muscle Wasting Disorders: Used in conditions like muscular dystrophy to slow muscle loss.

    • Goldspink, G. (2015). Mechano growth factor (MGF) and its role in muscle regeneration and hypertrophy. Journal of Muscle Research and Cell Motility, 36(4), 243-256.

    • McCall, G. E., et al. (2016). The role of IGF-1 and its splice variants in muscle repair and growth. Sports Medicine, 46(4), 389-399.

    • Kasemkijwattana, C., et al. (2017). PEGylated Mechano Growth Factor: A potential therapeutic for muscle repair and regeneration. Regenerative Medicine, 12(3), 275-284.

    • Sakuma, K., et al. (2018). The effect of PEG-MGF on satellite cells and muscle hypertrophy in aging populations. Journal of Geriatric Medicine, 31(2), 225-234.

    • Hameed, M., et al. (2019). The role of MGF in muscle recovery and injury rehabilitation: A clinical perspective. Journal of Orthopedic and Sports Physical Therapy, 49(3), 174-182.

    • Zhang, L., et al. (2020). The impact of PEG-MGF on musculoskeletal recovery and tissue repair. Frontiers in Physiology, 11, 467.

    • Watanabe, K., et al. (2019). PEG-MGF and its effects on muscle hypertrophy and bone healing: A comprehensive review. Journal of Bone and Mineral Research, 34(5), 1004-1011.

    • Damas, F., et al. (2020). Satellite cell activation and muscle hypertrophy: The influence of PEG-MGF. Medicine and Science in Sports and Exercise, 52(5), 1058-1064.

    • Gordon, B. S., et al. (2021). PEGylated growth factors: Therapeutic potential in muscle-wasting diseases. Current Opinion in Clinical Nutrition and Metabolic Care, 24(4), 339-345.

    • Stewart, C. E., et al. (2020). PEG-MGF for muscle repair and performance enhancement: Mechanisms and clinical applications. British Journal of Sports Medicine, 54(3), 190-197.