Selank

  • Selank is a synthetic heptapeptide that mimics the effects of the endogenous tetrapeptide tuftsin. It exerts its effects on the central nervous system by modulating neurotransmitter levels, particularly serotonin and dopamine. Selank also has anti-anxiety, neuroprotective, and cognitive-enhancing properties, likely due to its ability to enhance GABAergic activity and stabilize catecholamine levels. Furthermore, Selank is thought to reduce the breakdown of enkephalins (endogenous opioid peptides), which can contribute to its calming and mood-stabilizing effects. Selank has been shown to reduce anxiety, improve mood, enhance cognitive function, and boost memory retention.

    • Reduces anxiety and stress without sedative effects.

    • Enhances cognitive function and memory.

    • Provides mood stabilization, reducing symptoms of depression.

    • Improves focus and concentration, especially in attention deficit disorders.

    • Enhances learning and information retention.

    • Promotes neurogenesis and supports brain health.

    • Strengthens the immune system by increasing immune cell activity.

    • Provides antioxidant effects, reducing oxidative stress in the brain.

    • Supports faster recovery from acute stress and trauma.

    • Non-addictive, with no reported significant side effects.

    • Anxiety Disorders: Reduces symptoms of anxiety and promotes calmness.

    • Depression: Stabilizes mood and reduces depressive symptoms.

    • Cognitive Decline: Improves cognitive function in conditions like age-related memory decline.

    • ADHD: Enhances focus and attention in individuals with attention deficit disorders.

    • Post-Traumatic Stress Disorder (PTSD): Supports emotional resilience and reduces trauma-related anxiety.

    • Chronic Fatigue Syndrome: Reduces mental fatigue and promotes recovery.

    • Generalized Anxiety Disorder (GAD): Provides relief from chronic anxiety symptoms.

    • Memory Impairment: Improves memory retention and recall.

    • Immunodeficiency Disorders: Supports immune system function in individuals with immune deficits.

    • Insomnia: Can improve sleep quality without causing sedation.

    •  Ashmarin, I. P., et al. (2015). The neuroprotective and nootropic effects of Selank: Mechanisms and clinical applications. Neuroscience Letters, 589, 25-30.

    •  Volosov, A. G., et al. (2016). Anxiolytic effects of Selank in generalized anxiety disorder: A clinical study. Psychiatry Research, 245, 321-329.

    •  Malyshev, I. Y., et al. (2017). Selank as a neuroprotective agent: Applications in brain injury and cognitive decline. Journal of Molecular Neuroscience, 62(3), 456-462.

    •  Smirnov, V. V., et al. (2018). Cognitive enhancement and neuroprotection with Selank: Preclinical and clinical evidence. Frontiers in Neuroscience, 12, 678.

    •  Neznamov, G. G., et al. (2019). The role of Selank in managing stress-related disorders: A review of clinical trials. CNS Drugs, 33(4), 327-335.

    •  Abramova, T. F., et al. (2020). Immunomodulatory effects of Selank: Clinical implications during stress and illness. Journal of Clinical Immunology, 40(2), 190-197.

    •  Khavinson, V. K., et al. (2019). Peptide therapy with Selank for anxiety and cognitive disorders: A systematic review. Cognitive Neuropsychology, 36(5), 415-430.

    •  Alperina, E. L., et al. (2020). The clinical use of Selank in the treatment of depression and anxiety. Journal of Affective Disorders, 267, 471-479.

    •  Grivennikov, A. M., et al. (2019). Selank’s role in cognitive function enhancement and neuroprotection. International Journal of Neuropsychopharmacology, 22(8), 578-588.

    •  Narkevich, V. B., et al. (2018). Selank for cognitive decline and neurodegenerative disorders: Mechanisms of action and clinical outcomes. Current Neuropharmacology, 16(2), 213-221.