Tadalafil

  • Tadalafil works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme that degrades cyclic guanosine monophosphate (cGMP). Increased levels of cGMP promote smooth muscle relaxation and vasodilation, improving blood flow to specific areas, particularly the corpus cavernosum in the penis, which facilitates erections in response to sexual stimulation. Tadalafil also promotes vasodilation in the pulmonary and systemic vasculature, which is useful in the treatment of pulmonary arterial hypertension (PAH) and benign prostatic hyperplasia (BPH).

    • Erectile Dysfunction (ED): Improves erectile function by enhancing blood flow to the penis.

    • Pulmonary Arterial Hypertension (PAH): Lowers pulmonary artery pressure and improves exercise capacity.

    • Benign Prostatic Hyperplasia (BPH): Reduces urinary symptoms related to BPH by relaxing smooth muscle in the bladder and prostate.

    • Raynaud’s Phenomenon: May reduce vasospasm and improve blood flow in patients with Raynaud's disease.

    • Endothelial Dysfunction: Improves endothelial function by enhancing nitric oxide-mediated vasodilation.

    • Exercise Performance: May improve exercise capacity by enhancing oxygenation and blood flow in individuals with cardiovascular or pulmonary limitations.

    • Altitude Sickness: Used off-label to reduce pulmonary hypertension associated with high altitudes.

    • Heart Failure: Potentially beneficial in reducing pulmonary artery pressure in heart failure patients.

    • Prostate Cancer: Used in clinical research to enhance recovery of erectile function after prostate surgery.

    • Vascular Health: Enhances overall vascular function by promoting blood vessel relaxation and reducing vascular resistance.

    • Long Duration of Action: Provides up to 36 hours of therapeutic effects, offering flexibility for erectile function without the need to time dosing closely before sexual activity.

    • Improves Erectile Function: Facilitates natural erections in response to sexual stimulation by enhancing blood flow to the penis.

    • Reduces Pulmonary Hypertension: Lowers pulmonary blood pressure, improving oxygenation and exercise capacity.

    • Supports Prostate Health: Reduces urinary symptoms associated with benign prostatic hyperplasia.

    • Enhances Endothelial Health: Improves endothelial function, supporting overall vascular health.

    • Improves Exercise Capacity: Beneficial for patients with pulmonary arterial hypertension or cardiovascular limitations by enhancing blood flow and oxygen delivery.

    • Reduces Raynaud's Symptoms: Improves blood flow and reduces vasospasm in patients with Raynaud's phenomenon.

    • Minimal Side Effects: Generally well-tolerated with fewer side effects due to its longer half-life.

    • Potential Neuroprotective Effects: Research suggests tadalafil may support neural recovery in certain conditions like stroke recovery.

    • Convenient Once-Daily Dosing: For conditions like PAH or BPH, tadalafil is effective with once-daily administration.